Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Tissue-resident macrophages in omentum promote metastatic spread of ovarian cancer.

The Journal of experimental medicine - 6 Apr 2020

Etzerodt Anders, Moulin Morgane, Doktor Thomas Koed, Delfini Marcello, Mossadegh-Keller Noushine, Bajenoff Marc, Sieweke Michael H, Moestrup Søren Kragh, Auphan-Anezin Nathalie, Lawrence Toby

Abstract excerpt

Experimental and clinical evidence suggests that tumor-associated macrophages (TAMs) play important roles in cancer progression. Here, we have characterized the ontogeny and function of TAM subsets in a mouse model of metastatic ovarian cancer that is representative for visceral peritoneal metastasis. We show that the omentum is a critical premetastatic niche for development of invasive disease in this model and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antigens, CD
Share to Antigens, Differentiation, Myelomonocytic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to CD163 Antigen

Share to Macrophages

Share to Ovarian Neoplasms

Share to Peritoneal Neoplasms

Share to Receptors, Cell Surface

Share to Transcriptome

Source

Open in PubMed Open full text

Identifiers

PMID: 31951251
DOI: 10.1084/jem.20191869
PMCID: PMC7144521

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Tissue-resident macrophages in omentum promote metastatic spread of ovarian cancer.PMID 31951251Read ↗

The omentum, a niche for premetastatic ovarian cancerSemantic proximity Read ↗

Adipocytes are dispensable in shaping the ovarian cancer tumor microenvironment in the omentumSemantic proximity Read ↗

CD300e is a driver of the immunosuppressive tumor microenvironment and colorectal cancer progression via macrophage reprogrammingSemantic proximity Read ↗

Single-cell analysis identifies distinct macrophage phenotypes associated with pro-disease and pro-resolving functions in the endometriotic nicheSemantic proximity Read ↗

ITLN1 modulates invasive potential and metabolic reprogramming of ovarian cancer cells in omental microenvironmentSemantic proximity Read ↗

Single-cell analysis identifies distinct macrophage phenotypes associated with prodisease and proresolving functions in the endometriotic niche.Semantic proximity Read ↗

Tumor-associated macrophages (TAMs) depend on ZEB1 for their cancer-promoting roles.Semantic proximity Read ↗

Regulation of the bi-directional cross-talk between ovarian cancer cells and adipocytes by SPARCSemantic proximity Read ↗

Leader cells promote immunosuppression to drive ovarian cancer progression in vivoSemantic proximity Read ↗

Expression of the homeobox gene HOXA9 in ovarian cancer induces peritoneal macrophages to acquire an M2 tumor-promoting phenotype.Semantic proximity Read ↗

Heme oxygenase-1 expressing omental macrophages as a therapeutic target in ovarian high grade serous carcinomaSemantic proximity Read ↗

Preferential attachment of peritoneal tumor metastases to omental immune aggregates and possible role of a unique vascular microenvironment in metastatic survival and growth.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.