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Heme oxygenase-1 expressing omental macrophages as a therapeutic target in ovarian high grade serous carcinoma

2023-07-19

Abstract excerpt

Ovarian high grade serous carcinoma (HGSC) remains a disease of poor prognosis that is unresponsive to current immune checkpoint inhibitors. Although PI3K pathway alterations are common in HGSC, attempts to target this pathway have been unsuccessful. We hypothesised aberrant PI3K pathway activation may alter the HGSC immune microenvironment and present a novel targeting strategy. We used both murine models and HGS...

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Literature Corpus work
3d520b72-4eb7-5e51-b72b-e8f9f626513a
DOI
10.1101/2023.07.18.549474
Open publication

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Heme oxygenase-1 expressing omental macrophages as a therapeutic target in ovarian high grade serous carcinomaDOI 10.1101/2023.07.18.549474
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