Article

CD24 Acts as an Evolutionarily Conserved Innate Immune Checkpoint in Colorectal Cancer

2026-08-26

Abstract excerpt

Checkpoint immunotherapy has transformed cancer treatment, yet current approaches targeting adaptive immunity benefit only a subset of patients, leaving innate immunity as a largely untapped therapeutic frontier. Here, we identify CD24 as an innate immune checkpoint that protects colorectal tumors from macrophage-mediated clearance through an evolutionarily conserved recognition mechanism. Using zebrafish xenograf...

Topics

Open a Topic to create a Post that cites this publication.

Uncategorized literature

Identifiers and source

Literature Corpus work: f256cc0a-de5f-5b74-9ff2-ba556e3360e7
DOI: 10.64898/2026.08.25.746757

Open publication

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Click a neighbor to travelStep 1 · 12 closest

CD24 Acts as an Evolutionarily Conserved Innate Immune Checkpoint in Colorectal CancerDOI 10.64898/2026.08.25.746757Read

CD300e is a driver of the immunosuppressive tumor microenvironment and colorectal cancer progression via macrophage reprogrammingSemantic proximity Read

CD47 predominates over CD24 as a macrophage immune checkpoint in cancerSemantic proximity Read

Novel insights into the function of CD24 : A driving force in cancerSemantic proximity Read

Surprising magic of CD24 beyond cancerSemantic proximity Read

SLC39-driven zinc influx orchestrates pleiotropic tumor–immune crosstalk to establish an immune-suppressive microenvironment in colorectal cancerSemantic proximity Read

Tissue-resident macrophages in omentum promote metastatic spread of ovarian cancer.Semantic proximity Read

Tumor-associated macrophages employ immunoediting mechanisms in colorectal tumor progression: Current research in Macrophage repolarization immunotherapy.Semantic proximity Read

Genotype-phenotype mapping identifies fetal-like CD55 <sup>+</sup> immunoregulatory cancer cells as mediators of immune escape in colorectal cancerSemantic proximity Read

Unravelling CD24 ‐ Siglec‐10 pathway: Cancer immunotherapy from basic science to clinical studiesSemantic proximity Read

VSIG4-Expressing Macrophages Contribute To Anti-Parasitic And Anti-Metastatic Responses In The Peritoneal CavitySemantic proximity Read

The clinical and immune features of CD14 in colorectal cancer identified via large-scale analysis.Semantic proximity Read

Utilizing multimodal mass spectrometry imaging for profiling immune cell composition and N-glycosylation across colorectal carcinoma disease progressionSemantic proximity Read