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Article

ITLN1 modulates invasive potential and metabolic reprogramming of ovarian cancer cells in omental microenvironment

15 Jul 2020

Abstract excerpt

Advanced ovarian cancer usually spreads to the omentum. However, the omental cell-derived molecular determinants modulating its progression have not been thoroughly characterized. Here, we show that circulating ITLN1 has prognostic significance in patients with advanced ovarian cancer. Further studies demonstrate that ITLN1 suppresses lactotransferrin's effect on ovarian cancer cell invasion potential and...

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PMID: 32669559
DOI: 10.1038/s41467-020-17383-2

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