Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Tumor-associated macrophages (TAMs) depend on ZEB1 for their cancer-promoting roles.

The EMBO journal - 15 Nov 2017

Cortés Marlies, Sanchez-Moral Lidia, de Barrios Oriol, Fernández-Aceñero María J, Martínez-Campanario M C, Esteve-Codina Anna, Darling Douglas S, Győrffy Balázs, Lawrence Toby, Dean Douglas C, Postigo Antonio

Abstract excerpt

Accumulation of tumor-associated macrophages (TAMs) associates with malignant progression in cancer. However, the mechanisms that drive the pro-tumor functions of TAMs are not fully understood. ZEB1 is best known for driving an epithelial-to-mesenchymal transition (EMT) in cancer cells to promote tumor progression. However, a role for ZEB1 in macrophages and TAMs has not been studied. Here we describe that TAMs...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antigens, Differentiation, B-Lymphocyte
Share to Carcinogenesis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chemokine CCL2

Share to Colony-Stimulating Factors

Share to Macrophage Activation

Share to Matrix Metalloproteinase 9

Share to Receptors, CCR2

Share to Zinc Finger E-box-Binding Homeobox 1

Source

Open in PubMed Open full text

Identifiers

PMID: 29038174
DOI: 10.15252/embj.201797345
PMCID: PMC5686549

Genes

ZEB1
CCL2
CCR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Tumor-associated macrophages (TAMs) depend on ZEB1 for their cancer-promoting roles.PMID 29038174Read ↗

Dualistic role of ZEB1 and ZEB2 in tumor progressionSemantic proximity Read ↗

Zeb1 induces immune checkpoints to form an immunosuppressive envelope around invading cancer cellsSemantic proximity Read ↗

Pleiotropic Roles for ZEB1 in CancerSemantic proximity Read ↗

A stroma-corrected ZEB1 transcriptional signature is inversely associated with antitumor immune activity in breast cancerSemantic proximity Read ↗

ZEB1-regulated inflammatory phenotype in breast cancer cells.Semantic proximity Read ↗

Tumor-associated macrophages: functional diversity, clinical significance, and open questions.Semantic proximity Read ↗

Regulation of ZEB1 Function and Molecular Associations in Tumor Progression and MetastasisSemantic proximity Read ↗

The ZEB1/LAYN cascade promotes cancer cell malignant phenotypes and macrophage M2 polarization in gastric cancerSemantic proximity Read ↗

Functional Hierarchy and Cooperation of EMT Master Transcription Factors in Breast Cancer MetastasisSemantic proximity Read ↗

ZEB1 shapes AML immunological niches, suppressing CD8 T cell activity while fostering Th17 cell expansionSemantic proximity Read ↗

ZEB1 drives prometastatic actin cytoskeletal remodeling by downregulating miR-34a expressionSemantic proximity Read ↗

Wnt Signaling in the Phenotype and Function of Tumor-Associated Macrophages.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.