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Article

Expression of the homeobox gene HOXA9 in ovarian cancer induces peritoneal macrophages to acquire an M2 tumor-promoting phenotype.

The American journal of pathology - 1 Jan 2014

Ko Song Yi, Ladanyi Andras, Lengyel Ernst, Naora Honami

Abstract excerpt

Tumor-associated macrophages (TAMs) exhibit an M2 macrophage phenotype that suppresses anti-tumor immune responses and often correlates with poor outcomes in patients with cancer. Patients with ovarian cancer frequently present with peritoneal carcinomatosis, but the mechanisms that induce naïve...

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Source

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Identifiers

PMID: 24332016
DOI: 10.1016/j.ajpath.2013.09.017
PMCID: PMC3873497

Genes

HOXA9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24332016-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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