Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Duplicate genes and robustness to transient gene knock-downs in Caenorhabditis elegans.

Proceedings. Biological sciences - 7 Jan 2004

Conant Gavin C, Wagner Andreas

Abstract excerpt

We examine robustness to mutations in the nematode worm Caenorhabditis elegans and the role of single-copy and duplicate genes in it. We do so by integrating complete genome sequence and microarray gene expression data with results from a genome-scale study using RNA interference (RNAi) to temporarily eliminate the functions of more than 16000 worm genes. We found that 89% of single-copy and 96% of duplicate...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Caenorhabditis elegans
Share to Databases, Genetic
Share to Evolution, Molecular

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genes, Duplicate

Share to Multigene Family

Share to Oligonucleotide Array Sequence Analysis

Share to Phenotype

Share to RNA Interference

Source

Open in PubMed Open full text

Identifiers

PMID: 15002776
DOI: 10.1098/rspb.2003.2560
PMCID: PMC1691561

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Duplicate genes and robustness to transient gene knock-downs in Caenorhabditis elegans.PMID 15002776Read ↗

Combinatorial RNA interference in Caenorhabditis elegans reveals that redundancy between gene duplicates can be maintained for more than 80 million years of evolution.Semantic proximity Read ↗

Dynamic evolution of recently duplicated genes in <i>Caenorhabditis elegans</i>Semantic proximity Read ↗

Duplication and retention biases of essential and non-essential genes revealed by systematic knockdown analyses.Semantic proximity Read ↗

Evolution of duplicate genes versus genetic robustness against null mutations.Semantic proximity Read ↗

The origins of mutational robustness.Semantic proximity Read ↗

Diversification of small RNA pathways underlies germline RNAi incompetence in wild <i>C. elegans</i> strainsSemantic proximity Read ↗

Overcoming redundancy: an RNAi enhancer screen for morphogenesis genes in Caenorhabditis elegans.Semantic proximity Read ↗

Functional genomics: the worm scores a knockout.Semantic proximity Read ↗

Spontaneous mutations decrease sensitivity of gene expression to random environmental variation in Caenorhabditis elegans.Semantic proximity Read ↗

Preservation of genetic and regulatory robustness in ancient gene duplicates of Saccharomyces cerevisiae.Semantic proximity Read ↗

Role of duplicate genes in genetic robustness against null mutations.Semantic proximity Read ↗

Evolutionary change in the functional specificity of genes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.