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Article

A new hypothesis to explain disease dominance.

Trends in genetics : TIG - 1 Mar 2025

Juvik Brian, Falcucci Lara, Lundegaard Pia R, Stainier Didier Y R

Abstract excerpt

The onset and progression of dominant diseases are thought to result from haploinsufficiency or dominant negative effects. Here, we propose transcriptional adaptation (TA), a newly identified response to mRNA decay, as an additional cause of some dominant diseases. TA modulates the expression of so-called adapting genes, likely via mRNA decay products, resulting in genetic compensation or a worsening of the...

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Share to Cardiomyopathy, Hypertrophic
Share to Frontotemporal Lobar Degeneration
Share to Gene Expression Regulation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genes, Dominant

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Share to RNA Stability

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Identifiers

PMID: 39788833
DOI: 10.1016/j.tig.2024.11.009

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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