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Article

Modulated control of DNA supercoiling balance by the DNA-wrapping domain of bacterial gyrase.

Nucleic acids research - 28 Feb 2020

Hobson Matthew J, Bryant Zev, Berger James M

Abstract excerpt

Negative supercoiling by DNA gyrase is essential for maintaining chromosomal compaction, transcriptional programming, and genetic integrity in bacteria. Questions remain as to how gyrases from different species have evolved profound differences in their kinetics, efficiency, and extent of negative supercoiling. To explore this issue, we analyzed homology-directed mutations in the C-terminal, DNA-wrapping domain...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 31950157
DOI: 10.1093/nar/gkz1230
PMCID: PMC7038939

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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