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Article

RecA can stimulate the relaxation activity of topoisomerase I: Molecular basis of topoisomerase-mediated genome-wide transcriptional responses in Escherichia coli.

Nucleic acids research - 1 Jan 2007

Reckinger Amy R, Jeong Kyeong Soo, Khodursky Arkady B, Hiasa Hiroshi

Abstract excerpt

The superhelicity of the chromosome, which is controlled by DNA topoisomerases, modulates global gene expression. Investigations of transcriptional responses to the modulation of gyrase function have identified two types of topoisomerase-mediated transcriptional responses: (i) steady-state changes elicited by a mutation in gyrase, such as the D82G mutation in GyrA, and (ii) dynamic changes elicited by the...

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Identifiers

PMID: 17151069
DOI: 10.1093/nar/gkl981
PMCID: PMC1761438

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Source receipt: pubmed, retrieved 7 Sept 2026.

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