Article
The reverse gyrase helicase-like domain is a nucleotide-dependent switch that is attenuated by the topoisomerase domain.
Nucleic acids research - 1 Oct 2008
del Toro Duany Yoandris, Jungblut Stefan P, Schmidt Andreas S, Klostermeier Dagmar
Abstract excerpt
Reverse gyrase is a topoisomerase that introduces positive supercoils into DNA in an ATP-dependent manner. It is unique to hyperthermophilic archaea and eubacteria, and has been proposed to protect their DNA from damage at high temperatures. Cooperation between its N-terminal helicase-like and the C-terminal topoisomerase domain is required for positive supercoiling, but the precise role of the helicase-like...
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