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Article

A model for the mechanism of strand passage by DNA gyrase.

Proceedings of the National Academy of Sciences of the United States of America - 20 Jul 1999

Kampranis S C, Bates A D, Maxwell A

Abstract excerpt

The mechanism of type II DNA topoisomerases involves the formation of an enzyme-operated gate in one double-stranded DNA segment and the passage of another segment through this gate. DNA gyrase is the only type II topoisomerase able to introduce negative supercoils into DNA, a feature that requires the enzyme to dictate the directionality of strand passage. Although it is known that this is a consequence of the...

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Identifiers

PMID: 10411889
DOI: 10.1073/pnas.96.15.8414
PMCID: PMC17530

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