Article
A model for the mechanism of strand passage by DNA gyrase.
Proceedings of the National Academy of Sciences of the United States of America - 20 Jul 1999
Kampranis S C, Bates A D, Maxwell A
Abstract excerpt
The mechanism of type II DNA topoisomerases involves the formation of an enzyme-operated gate in one double-stranded DNA segment and the passage of another segment through this gate. DNA gyrase is the only type II topoisomerase able to introduce negative supercoils into DNA, a feature that requires the enzyme to dictate the directionality of strand passage. Although it is known that this is a consequence of the...
Topics
- Adenosine Triphosphatases
- Adenosine Triphosphate
- Binding Sites
- DNA
- DNA Topoisomerases, Type I
- DNA Topoisomerases, Type II
- DNA, Superhelical
- Escherichia coli
- Models, Molecular
- Mutation
- Nucleic Acid Conformation