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Article

Supercoiling Effects on Short-Range DNA Looping in E. coli.

PloS one - 1 Jan 2016

Mogil Lauren S, Becker Nicole A, Maher L James

Abstract excerpt

DNA-protein loops can be essential for gene regulation. The Escherichia coli lactose (lac) operon is controlled by DNA-protein loops that have been studied for decades. Here we adapt this model to test the hypothesis that negative superhelical strain facilitates the formation of short-range (6-8 DNA turns) repression loops in E. coli. The natural negative superhelicity of E. coli DNA is regulated by the interplay...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to DNA Topoisomerases, Type I

Share to Electrophoresis, Agar Gel

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Source

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Identifiers

PMID: 27783696
DOI: 10.1371/journal.pone.0165306
PMCID: PMC5081198

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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