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APOBEC3G cytosine deamination hotspots are defined by both sequence context and single-stranded DNA secondary structure

24 Apr 2013

Abstract excerpt

Apolipoprotein B mRNA-editing, enzyme-catalytic, polypeptide-like 3G (i.e., APOBEC3G or A3G) is an evolutionarily conserved cytosine deaminase that potently restricts human immunodeficiency virus type 1 (HIV-1), retrotransposons and other viruses. A3G has a nucleotide target site specificity for cytosine dinucleotides, though only certain cytosine dinucleotides are 'hotspots' for cytosine deamination, and others...

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PMID: 23620282
DOI: 10.1093/nar/gkt246

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