Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

MYC and Twist1 cooperate to drive metastasis by eliciting crosstalk between cancer and innate immunity

13 Jan 2020

Abstract excerpt

Metastasis is a major cause of cancer mortality. We generated an autochthonous transgenic mouse model whereby conditional expression of MYC and Twist1 enables hepatocellular carcinoma (HCC) to metastasize in >90% of mice. MYC and Twist1 cooperate and their sustained expression is required to elicit a transcriptional program associated with the activation of innate immunity, through secretion of a cytokinome that...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Immunotherapy and Biomarkers
Share to Immune cells in cancer
Share to Immunotherapy and Immune Responses

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 31933479
DOI: 10.7554/elife.50731

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

MYC and Twist1 cooperate to drive metastasis by eliciting crosstalk between cancer and innate immunityPMID 31933479Read ↗

Regulation of Cancer Cell Survival, Migration, and Invasion by Twist: AKT2 Comes to InterplaySemantic proximity Read ↗

A twist tale of cancer metastasis and tumor angiogenesis.Semantic proximity Read ↗

Advanced HCC precision modeling reveals divergent responses to combinatorial immunotherapySemantic proximity Read ↗

Tumor-associated macrophages (TAMs) depend on ZEB1 for their cancer-promoting roles.Semantic proximity Read ↗

TCF4 enhances hepatic metastasis of colorectal cancer by regulating tumor-associated macrophage via CCL2/CCR2 signaling.Semantic proximity Read ↗

Overexpressed <i>Malat1</i> Drives Metastasis through Inflammatory Reprogramming of Lung Adenocarcinoma MicroenvironmentSemantic proximity Read ↗

Twist1-induced suppression of oncogene-induced senescence in non-small cell lung cancer requires the transactivation domain of Twist1Semantic proximity Read ↗

Distinct functions of transforming growth factor-β signaling in c-MYC driven hepatocellular carcinoma initiation and progressionSemantic proximity Read ↗

M1 macrophage-mediated lymphangiogenesis aggravates liver fibrosis via MDK/YAP signaling pathwaySemantic proximity Read ↗

The Steroid Receptor Coactivator-1 Regulates Twist Expression and Promotes Breast Cancer MetastasisSemantic proximity Read ↗

Impaired lymphatic function accelerates cancer growth.Semantic proximity Read ↗

Molecular mechanisms of IL-33–mediated stromal interactions in cancer metastasisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.