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Article

A twist tale of cancer metastasis and tumor angiogenesis.

Histology and histopathology - 1 Nov 2015

Tseng Jen-Chieh, Chen Hsiao-Fan, Wu Kou-Juey

Abstract excerpt

Twist1 is an evolutionally conserved transcription factor. Originally identified in Drosophila as a key regulator for mesoderm development, it was later implicated in many human diseases, including Saethre-Chotzen syndrome and cancer. Twist1's involvement in cancer has been well recognized. Driven by hypoxia-induced factor-1 (HIF-1), Twist1 has been considered as a proto-oncogene and its overexpression has been...

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Source

Identifiers

PMID: 26084282
DOI: 10.14670/HH-11-638

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

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A twist tale of cancer metastasis and tumor angiogenesis.PMID 26084282Read ↗

Shake It Up Baby Now: The Changing Focus on TWIST1 and Epithelial to Mesenchymal Transition in Cancer and Other DiseasesSemantic proximity Read ↗

Direct regulation of TWIST by HIF-1alpha promotes metastasis.Semantic proximity Read ↗

TWIST activation by hypoxia inducible factor-1 (HIF-1): Implications in metastasis and developmentSemantic proximity Read ↗

Regulation of Cancer Cell Survival, Migration, and Invasion by Twist: AKT2 Comes to InterplaySemantic proximity Read ↗

A tale with a Twist: a developmental gene with potential relevance for metabolic dysfunction and inflammation in adipose tissueSemantic proximity Read ↗

TWIST1 expression is associated with high-risk neuroblastoma and promotes primary and metastatic tumor growthSemantic proximity Read ↗

AKT-ions with a TWIST between EMT and MET.Semantic proximity Read ↗

Involvement of the transcription factor twist in phenotype alteration through epithelial–mesenchymal transition in lung cancer cellsSemantic proximity Read ↗

Emerging role of Twist1 in fibrotic diseasesSemantic proximity Read ↗

Twist‐ing cell fate: Mechanistic insights into the role of twist in lineage specification/differentiation and tumorigenesisSemantic proximity Read ↗

Over-Expressed Twist Associates with Markers of Epithelial Mesenchymal Transition and Predicts Poor Prognosis in Breast Cancers via ERK and Akt ActivationSemantic proximity Read ↗

High TWIST1 mRNA expression is associated with poor prognosis in lymph node-negative and estrogen receptor-positive human breast cancer and is co-expressed with stromal as well as ECM related genesSemantic proximity Read ↗

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