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Article

Twist1-induced suppression of oncogene-induced senescence in non-small cell lung cancer requires the transactivation domain of Twist1

22 May 2025

Abstract excerpt

Non-small cell lung carcinoma (NSCLC) is a major cause of cancer mortality. High expression of the epithelial-to-mesenchymal transition transcription factor (EMT-TF) Twist1 is strongly associated with metastatic cancers and with treatment resistance. Twist1 can also upregulate O-GlcNAcylation to suppress fail-safe programs such as Kras G12D oncogene-induced senescence (OIS) that accelerates NSCLC tumorigenesis....

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PMID: 40409044
DOI: 10.1016/j.neo.2025.101179

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