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The Steroid Receptor Coactivator-1 Regulates Twist Expression and Promotes Breast Cancer Metastasis

21 Apr 2009

Abstract excerpt

In breast cancer, steroid receptor coactivator-1 (SRC-1) expression positively correlates with HER2 expression and poor prognosis. In mouse mammary tumor virus-polyoma middle T (PyMT) breast cancer mouse model, SRC-1 strongly promotes mammary tumor metastasis. However, the molecular targets and mechanisms that mediate the role of SRC-1 in metastasis are unknown. In this study, SRC-1 wild-type (WT) and knockout...

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PMID: 19383905
DOI: 10.1158/0008-5472.can-08-4389

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