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Article

Molecular mechanisms of IL-33–mediated stromal interactions in cancer metastasis

17 Oct 2018

Abstract excerpt

Molecular mechanisms underlying the cancer stroma in metastasis need further exploration. Here, we discovered that cancer-associated fibroblasts (CAFs) produced high levels of IL-33 that acted on tumor-associated macrophages (TAMs), causing them to undergo the M1 to M2 transition. Genomic profiling of metastasis-related genes in the IL-33-stimulated TAMs showed a >200-fold increase of MMP9. Signaling analysis...

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PMID: 30333314
DOI: 10.1172/jci.insight.122375

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