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Article

TCF4 enhances hepatic metastasis of colorectal cancer by regulating tumor-associated macrophage via CCL2/CCR2 signaling.

Cell death & disease - 27 Sept 2021

Tu Wei, Gong Jin, Zhou Zhenzhen, Tian Dean, Wang Zhijun

Abstract excerpt

Colorectal cancer (CRC) liver metastasis is a significant clinical problem for which better therapies are urgently needed. Tumor-associated macrophage, a major cell population in the tumor microenvironment, is a known contributor to primary cancer progression and cancer metastasis. Here, we found TAM recruitment and M2 polarization were increased in the hepatic metastatic lesion compared with the primary site of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34580284
DOI: 10.1038/s41419-021-04166-w
PMCID: PMC8476489

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