External validation of models for KIR2DS1/KIR3DL1-informed selection of hematopoietic cell donors fails.

doi:10.1182/blood.2019002887

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

External validation of models for KIR2DS1/KIR3DL1-informed selection of hematopoietic cell donors fails.

Blood - 16 Apr 2020

Schetelig Johannes, Baldauf Henning, Heidenreich Falk, Massalski Carolin, Frank Sandra, Sauter Jürgen, Stelljes Matthias, Ayuk Francis Ayuketang, Bethge Wolfgang A, Bug Gesine, Klein Stefan, Wendler Sarah, Lange Vinzenz, de Wreede Liesbeth C, Fürst Daniel, Kobbe Guido, Ottinger Hellmut D, Beelen Dietrich W, Mytilineos Joannis, Fleischhauer Katharina, Schmidt Alexander H, Bornhäuser Martin

Abstract excerpt

Several studies suggest that harnessing natural killer (NK) cell reactivity mediated through killer cell immunoglobulin-like receptors (KIRs) could reduce the risk of relapse after allogeneic hematopoietic cell transplantation. Based on one promising model, information on KIR2DS1 and KIR3DL1 and their cognate ligands can be used to classify donors as KIR-advantageous or KIR-disadvantageous. This study was aimed...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Donor Selection

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Graft vs Host Disease

Share to Myelodysplastic Syndromes

Share to Proportional Hazards Models

Share to Receptors, KIR

Share to Receptors, KIR3DL1

Share to Transplantation, Homologous

Share to Unrelated Donors

Source

Open in PubMed Open full text

Identifiers

PMID: 31932846
DOI: 10.1182/blood.2019002887
PMCID: PMC7162689

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

External validation of models for KIR2DS1/KIR3DL1-informed selection of hematopoietic cell donors fails.PMID 31932846Read ↗

Haplotype Motif-Based Models for KIR-Genotype Informed Selection of Hematopoietic Cell Donors Fail to Predict Outcome of Patients With Myelodysplastic Syndromes or Secondary Acute Myeloid Leukemia.Semantic proximity Read ↗

Missing KIR ligands are associated with less relapse and increased graft-versus-host disease (GVHD) following unrelated donor allogeneic HCT.Semantic proximity Read ↗

HLA-C-dependent prevention of leukemia relapse by donor activating KIR2DS1.Semantic proximity Read ↗

Integrating killer cell immunoglobulin-like receptor highresolution genotyping for predicting transplant outcomes in allogeneic hematopoietic stem cell transplantation.Semantic proximity Read ↗

KIR3DL1/HLA-B Subtypes Govern Acute Myelogenous Leukemia Relapse After Hematopoietic Cell Transplantation.Semantic proximity Read ↗

The beneficial impact of missing KIR ligands and absence of donor KIR2DS3 gene on outcome following unrelated hematopoietic SCT for myeloid leukemia in the Chinese population.Semantic proximity Read ↗

Improved outcome in HLA-identical sibling hematopoietic stem-cell transplantation for acute myelogenous leukemia predicted by KIR and HLA genotypes.Semantic proximity Read ↗

Prospective KIR genotype evaluation of hematopoietic cell donors is feasible with potential to benefit patients with AML.Semantic proximity Read ↗

Donor KIR genotype based outcome prediction after allogeneic stem cell transplantation: no land in sight.Semantic proximity Read ↗

Reduction of Relapse after Unrelated Donor Stem Cell Transplantation by KIR-Based Graft SelectionSemantic proximity Read ↗

KIR in Allogeneic Hematopoietic Stem Cell Transplantation: Need for a Unified Paradigm for Donor SelectionSemantic proximity Read ↗

Haploidentical hematopoietic transplantation from KIR ligand-mismatched donors with activating KIRs reduces nonrelapse mortality.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.