Article
The beneficial impact of missing KIR ligands and absence of donor KIR2DS3 gene on outcome following unrelated hematopoietic SCT for myeloid leukemia in the Chinese population.
Bone marrow transplantation - 1 Oct 2010
Wu G Q, Zhao Y M, Lai X Y, Luo Y, Tan Y M, Shi J M, Li L, Zheng W Y, Zhang J, Hu X R, Jin A Y, He J S, Xie W Z, Ye X J, Cai Z, Lin M F, Huang H
Abstract excerpt
The effect of natural killer (NK) cell alloreactivity on the outcome of unrelated hematopoietic SCT (HSCT) remains a topic of debate. NK cell alloreactivity after allogeneic HSCT is regulated by killer-cell Ig-like receptors (KIRs). To investigate the influence of KIRs on outcome after unrelated HSCT, we retrospectively analyzed the HLA and KIR genotypes of 116 donor-recipient pairs. We found that missing KIR...
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