Donor KIR genotype based outcome prediction after allogeneic stem cell transplantation: no land in sight.

doi:10.3389/fimmu.2024.1350470

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Article

Donor KIR genotype based outcome prediction after allogeneic stem cell transplantation: no land in sight.

Frontiers in immunology - 1 Jan 2024

Schetelig Johannes, Baldauf Henning, Heidenreich Falk, Hoogenboom Jorinde D, Spellman Stephen R, Kulagin Alexander, Schroeder Thomas, Sengeloev Henrik, Dreger Peter, Forcade Edouard, Vydra Jan, Wagner-Drouet Eva Maria, Choi Goda, Paneesha Shankara, Miranda Nuno A A, Tanase Alina, de Wreede Liesbeth C, Lange Vinzenz, Schmidt Alexander H, Sauter Jürgen, Fein Joshua A, Bolon Yung-Tsi, He Meilun, Marsh Steven G E, Gadalla Shahinaz M, Paczesny Sophie, Ruggeri Annalisa, Chabannon Christian, Fleischhauer Katharina

Abstract excerpt

Optimizing natural killer (NK) cell alloreactivity could further improve outcome after allogeneic hematopoietic cell transplantation (alloHCT). The donor's Killer-cell Immunoglobulin-like Receptor (KIR) genotype may provide important information in this regard. In the past decade, different models have been proposed aiming at maximizing NK cell activation by activating KIR-ligand interactions or minimizing...

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PMID: 38629074
DOI: 10.3389/fimmu.2024.1350470
PMCID: PMC11019434

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