Article
Improved outcome in HLA-identical sibling hematopoietic stem-cell transplantation for acute myelogenous leukemia predicted by KIR and HLA genotypes.
Blood - 15 Jun 2005
Hsu Katharine C, Keever-Taylor Carolyn A, Wilton Andrew, Pinto Clara, Heller Glenn, Arkun Knarik, O'Reilly Richard J, Horowitz Mary M, Dupont Bo
Abstract excerpt
Inhibitory killer immunoglobulin (Ig)-like receptors (KIRs) recognize HLA-C and -B epitopes on target cells, thereby regulating natural killer (NK) cell activity. In 178 patients receiving T-cell-depleted HLA-identical sibling transplants for acute myelogenous leukemia (AML), chronic myelogenous leukemia (CML), acute lymphoblastic leukemia (ALL), or myelodysplastic syndrome (MDS), analysis of donor KIR genotype...
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