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Reduction of Relapse after Unrelated Donor Stem Cell Transplantation by KIR-Based Graft Selection

7 Feb 2017

Abstract excerpt

Besides donor T cells, natural killer (NK) cells are considered to have a major role in preventing relapse after allogeneic hematopoietic stem cell transplantation (HSCT). After T-cell-depleted haploidentical HSCT, a strong NK alloreactivity has been described. These effects have been attributed to killer-cell immunoglobulin-like receptors (KIR). Abundant reports suggest a major role of KIR not only on outcome...

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PMID: 28228753
DOI: 10.3389/fimmu.2017.00041

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