Haplotype Motif-Based Models for KIR-Genotype Informed Selection of Hematopoietic Cell Donors Fail to Predict Outcome of Patients With Myelodysplastic Syndromes or Secondary Acute Myeloid Leukemia.

doi:10.3389/fimmu.2020.584520

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Article

Haplotype Motif-Based Models for KIR-Genotype Informed Selection of Hematopoietic Cell Donors Fail to Predict Outcome of Patients With Myelodysplastic Syndromes or Secondary Acute Myeloid Leukemia.

Frontiers in immunology - 1 Jan 2020

Schetelig Johannes, Baldauf Henning, Koster Linda, Kuxhausen Michelle, Heidenreich Falk, de Wreede Liesbeth C, Spellman Stephen, van Gelder Michel, Bruno Benedetto, Onida Francesco, Lange Vinzenz, Massalski Carolin, Potter Victoria, Ljungman Per, Schaap Nicolaas, Hayden Patrick, Lee Stephanie J, Kröger Nicolaus, Hsu Kathy, Schmidt Alexander H, Yakoub-Agha Ibrahim, Robin Marie

Abstract excerpt

Results from registry studies suggest that harnessing Natural Killer (NK) cell reactivity mediated through Killer cell Immunoglobulin-like Receptors (KIR) could reduce the risk of relapse after allogeneic Hematopoietic Cell Transplantation (HCT). Several competing models have been developed to classify donors as KIR-advantageous or disadvantageous. Basically, these models differ by grouping donors based on...

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Identifiers

PMID: 33542712
DOI: 10.3389/fimmu.2020.584520
PMCID: PMC7851088

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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