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Article

Missing KIR ligands are associated with less relapse and increased graft-versus-host disease (GVHD) following unrelated donor allogeneic HCT.

Blood - 1 Jun 2007

Miller Jeffery S, Cooley Sarah, Parham Peter, Farag Sherif S, Verneris Michael R, McQueen Karina L, Guethlein Lisbeth A, Trachtenberg Elizabeth A, Haagenson Michael, Horowitz Mary M, Klein John P, Weisdorf Daniel J

Abstract excerpt

Natural killer (NK) cells can alter the outcome of hematopoietic cell transplantation (HCT) if donor alloreactivity targets the recipient. Since most NK cells express inhibitory killer-immunoglobulin receptors (KIRs), we hypothesized that the susceptibility of recipient cells to donor NK cell-mediated lysis is genetically predetermined by the absence of known KIR ligands. We analyzed data from 2062 patients...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Leukemia, Myelogenous, Chronic, BCR-ABL Positive

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Identifiers

PMID: 17317850
DOI: 10.1182/blood-2007-01-065383
PMCID: PMC1885526

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