KIR3DL1/HLA-B Subtypes Govern Acute Myelogenous Leukemia Relapse After Hematopoietic Cell Transplantation.

doi:10.1200/JCO.2016.70.7059

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

KIR3DL1/HLA-B Subtypes Govern Acute Myelogenous Leukemia Relapse After Hematopoietic Cell Transplantation.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 10 Jul 2017

Boudreau Jeanette E, Giglio Fabio, Gooley Ted A, Stevenson Philip A, Le Luduec Jean-Benoît, Shaffer Brian C, Rajalingam Raja, Hou Lihua, Hurley Carolyn Katovich, Noreen Harriet, Reed Elaine F, Yu Neng, Vierra-Green Cynthia, Haagenson Michael, Malkki Mari, Petersdorf Effie W, Spellman Stephen, Hsu Katharine C

Abstract excerpt

Purpose Disease relapse remains a major challenge to successful outcomes in patients who undergo allogeneic hematopoietic cell transplantation (HCT). Donor natural killer (NK) cell alloreactivity in HCT can control leukemic relapse, but capturing alloreactivity in HLA-matched HCT has been elusive. HLA expression on leukemia cells-upregulated in the post-HCT environment-signals for NK cell inhibition via...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cytotoxicity Tests, Immunologic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to HLA-B Antigens

Share to Killer Cells, Natural

Share to Receptors, KIR

Share to Receptors, KIR3DL1

Share to Recurrence

Share to Survival Rate

Share to Transplantation, Homologous

Source

Open in PubMed Open full text

Identifiers

PMID: 28520526
DOI: 10.1200/JCO.2016.70.7059
PMCID: PMC5501362

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

KIR3DL1/HLA-B Subtypes Govern Acute Myelogenous Leukemia Relapse After Hematopoietic Cell Transplantation.PMID 28520526Read ↗

HLA-A alleles influencing NK cell function impact AML relapse following allogeneic hematopoietic cell transplantation.Semantic proximity Read ↗

External validation of models for KIR2DS1/KIR3DL1-informed selection of hematopoietic cell donors fails.Semantic proximity Read ↗

Molecular relapse monitoring reveals the domination of impaired NK cell education over impaired inhibition in missing KIR-ligand recognition in patients after unrelated hematopoietic stem cell transplantation for malignant diseases.Semantic proximity Read ↗

HLA-C-dependent prevention of leukemia relapse by donor activating KIR2DS1.Semantic proximity Read ↗

KIR and HLA genotypes predictive of low-affinity interactions are associated with lower relapse in autologous hematopoietic cell transplantation for acute myeloid leukemia.Semantic proximity Read ↗

Influence of Killer Immunoglobulin-Like Receptors and Somatic Mutations on Transplant Outcomes in Acute Myeloid Leukemia.Semantic proximity Read ↗

Donor and host coexpressing KIR ligands promote NK education after allogeneic hematopoietic stem cell transplantationSemantic proximity Read ↗

Integrating killer cell immunoglobulin-like receptor highresolution genotyping for predicting transplant outcomes in allogeneic hematopoietic stem cell transplantation.Semantic proximity Read ↗

Donor selection for natural killer cell receptor genes leads to superior survival after unrelated transplantation for acute myelogenous leukemia.Semantic proximity Read ↗

Prospective KIR genotype evaluation of hematopoietic cell donors is feasible with potential to benefit patients with AML.Semantic proximity Read ↗

Following Transplantation for Acute Myelogenous Leukemia, Donor KIR Cen B02 Better Protects against Relapse than KIR Cen B01.Semantic proximity Read ↗

Haploidentical hematopoietic transplantation from KIR ligand-mismatched donors with activating KIRs reduces nonrelapse mortality.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.