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Article

HLA-C-dependent prevention of leukemia relapse by donor activating KIR2DS1.

The New England journal of medicine - 30 Aug 2012

Venstrom Jeffrey M, Pittari Gianfranco, Gooley Ted A, Chewning Joseph H, Spellman Stephen, Haagenson Michael, Gallagher Meighan M, Malkki Mari, Petersdorf Effie, Dupont Bo, Hsu Katharine C

Abstract excerpt

BACKGROUND: Of the cancers treated with allogeneic hematopoietic stem-cell transplantation (HSCT), acute myeloid leukemia (AML) is most sensitive to natural killer (NK)-cell reactivity. The activating killer-cell immunoglobulin-like receptor (KIR) 2DS1 has ligand specificity for HLA-C2 antigens and activates NK cells in an HLA-dependent manner. Donor-derived NK reactivity controlled by KIR2DS1 and HLA could have...

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Share to HLA-C Antigens
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22931314
DOI: 10.1056/NEJMoa1200503
PMCID: PMC3767478

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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