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Article

Prospective KIR genotype evaluation of hematopoietic cell donors is feasible with potential to benefit patients with AML.

Blood advances - 13 Apr 2021

Shaffer Brian C, Le Luduec Jean-Benoit, Park Soo, Devlin Sean, Archer Anne, Davis Eric, Cooper Candice, Nhaissi Melissa, Suri Beth, Wells Deborah, Tamari Roni, Papadopoulos Esperanza, Jakubowski Ann A, Giralt Sergio, Hsu Katharine C

Abstract excerpt

Donor KIR and recipient HLA combinations that minimize inhibition and favor activation of the NK repertoire are associated with improved outcomes after allogeneic hematopoietic cell transplantation (HCT) in patients with myeloid neoplasia. We prospectively evaluated a weighted donor ranking algorithm designed to prioritize HLA-compatible unrelated donors (URDs) with weak inhibitory KIR3DL1/HLA-Bw4 interaction,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33843984
DOI: 10.1182/bloodadvances.2020002701
PMCID: PMC8045509

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