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Article

Senescent mesenchymal stem cells remodel extracellular matrix driving breast cancer cells to a more-invasive phenotype.

Journal of cell science - 23 Jan 2020

Ghosh Deepraj, Mejia Pena Carolina, Quach Nhat, Xuan Botai, Lee Amy H, Dawson Michelle R

Abstract excerpt

Mesenchymal stem cells (MSCs) are essential for the regenerative process; however, biological aging and environmental stress can induce senescence - an irreversible state of growth arrest - that not only affects the behavior of cells but also disrupts their ability to restore tissue integrity. While abnormal tissue properties, including increased extracellular matrix stiffness, are linked with the risk of...

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Identifiers

PMID: 31932504
DOI: 10.1242/jcs.232470
PMCID: PMC6983709

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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