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Article

Decellularized Extracellular Matrix Mitigates the Senescent Phenotype and Restores Osteogenic Potential in Human Mesenchymal Stromal Cells.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society - 1 Aug 2026

Dorais Connor J, Kruger Nikolia M, Ramos-Rodriguez David H, Lee Mark A, Kent Leach J

Abstract excerpt

Autologous cell-based approaches for bone repair using mesenchymal stromal cells (MSCs) in older patients are limited in part by cellular senescence, resulting in impaired MSC self-renewal and differentiation. Currently, the field lacks a standardized method to induce senescence in human MSCs and characterize them for experimental use, as well as effective strategies to mitigate the harmful effects of the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42595971
DOI: 10.1002/jor.70264
PMCID: PMC13473382

Genes

MSC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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