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Article

Compliant substrates mitigate the senescence associated phenotype of stress induced mesenchymal stromal cells.

Journal of biomedical materials research. Part A - 1 May 2024

Gresham Robert C H, Filler Andrea C, Fok Shierly W, Czachor Molly, Schmier Natalie, Pearson Claire, Bahney Chelsea, Leach J Kent

Abstract excerpt

Mesenchymal stromal cells (MSCs) are a promising cell population for musculoskeletal cell-based therapies due to their multipotent differentiation capacity and complex secretome. Cells from younger donors are mechanosensitive, evidenced by changes in cell morphology, adhesivity, and differentiation as a function of substrate stiffness in both two- and three-dimensional culture. However, MSCs from older...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38095311
DOI: 10.1002/jbm.a.37657
PMCID: PMC10948313

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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