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Article

Stromal-epithelial interactions in aging and cancer: senescent fibroblasts alter epithelial cell differentiation

18 Jan 2005

Abstract excerpt

Cellular senescence suppresses cancer by arresting cells at risk of malignant tumorigenesis. However, senescent cells also secrete molecules that can stimulate premalignant cells to proliferate and form tumors, suggesting the senescence response is antagonistically pleiotropic. We show that premalignant mammary epithelial cells exposed to senescent human fibroblasts in mice irreversibly lose differentiated...

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PMID: 15657080
DOI: 10.1242/jcs.01635

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