Article

Paracrine Signals from the Tumor Microenvironment Modulate Stem-Cell Collagen Interaction, Remodeling and Reprogramming Toward a Cancer-Associated Phenotype

2026-03-18

Abstract excerpt

The tumor microenvironment is continuously shaped by reciprocal interactions between malignant cells and stromal components, with mesenchymal stem cells (MSCs) serving as key regulators of extracellular matrix (ECM) deposition and remodeling. In this study, we examined how cancer cell-derived secretomes from two hematological cancer cell lines, RPMI 8226 (multiple myeloma) and HG-3 (B-cell leukemia), influence the...

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Literature Corpus work: a3561472-486f-508e-870b-0cf9c6f9a8ac
DOI: 10.20944/preprints202603.1408.v1

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