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Article

Senescent stromal cells induce cancer cell migration via inhibition of RhoA/ROCK/myosin-based cell contractility.

Oncotarget - 13 Oct 2015

Aifuwa Ivie, Giri Anjil, Longe Nick, Lee Sang Hyuk, An Steven S, Wirtz Denis

Abstract excerpt

Cells induced into senescence exhibit a marked increase in the secretion of pro-inflammatory cytokines termed senescence-associated secretory phenotype (SASP). Here we report that SASP from senescent stromal fibroblasts promote spontaneous morphological changes accompanied by an aggressive migratory behavior in originally non-motile human breast cancer cells. This phenotypic switch is coordinated, in space and...

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Identifiers

PMID: 26483365
DOI: 10.18632/oncotarget.5854
PMCID: PMC4741548

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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