Article
Identification of new genes associated to senescent and tumorigenic phenotypes in mesenchymal stem cells.
Scientific reports - 19 Dec 2017
Medeiros Tavares Marques Joana Cristina, Cornélio Déborah Afonso, Nogueira Silbiger Vivian, Ducati Luchessi André, de Souza Sandro, Batistuzzo de Medeiros Silvia Regina
Abstract excerpt
Although human mesenchymal stem cells (hMSCs) are a powerful tool for cell therapy, prolonged culture times result in replicative senescence or acquisition of tumorigenic features. To identify a molecular signature for senescence, we compared the transcriptome of senescent and young hMSCs with normal karyotype (hMSCs/n) and with a constitutional inversion of chromosome 3 (hMSC/inv). Senescent and young cells from...
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