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Article

Inheritance of a common androgen synthesis variant allele is associated with female COVID susceptibility in UK Biobank.

European journal of endocrinology - 12 May 2022

McManus Jeffrey M, Sabharwal Navin, Bazeley Peter, Sharifi Nima

Abstract excerpt

Context: A sex discordance in COVID exists, with males disproportionately affected. Although sex steroids may play a role in this discordance, no definitive genetic data exist to support androgen-mediated immune suppression neither for viral susceptibility nor for adrenally produced androgens. Objective: The common adrenal-permissive missense-encoding variant HSD3B1(1245C) that enables androgen synthesis from...

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Identifiers

PMID: 35521709
DOI: 10.1530/EJE-21-0996
PMCID: PMC9106901

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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