Genomic Characterization of Cholangiocarcinoma in Primary Sclerosing Cholangitis Reveals Therapeutic Opportunities.

doi:10.1002/hep.31110

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Genomic Characterization of Cholangiocarcinoma in Primary Sclerosing Cholangitis Reveals Therapeutic Opportunities.

Hepatology (Baltimore, Md.) - 1 Oct 2020

Goeppert Benjamin, Folseraas Trine, Roessler Stephanie, Kloor Matthias, Volckmar Anna-Lena, Endris Volker, Buchhalter Ivo, Stenzinger Albrecht, Grzyb Krzysztof, Grimsrud Marit M, Gornicka Barbara, von Seth Erik, Reynolds Gary M, Franke Andre, Gotthardt Daniel N, Mehrabi Arianeb, Cheung Angela, Verheij Joanne, Arola Johanna, Mäkisalo Heikki, Eide Tor J, Weidemann Sören, Cheville John C, Mazza Giuseppe, Hirschfield Gideon M, Ponsioen Cyriel Y, Bergquist Annika, Milkiewicz Piotr, Lazaridis Konstantinos N, Schramm Christoph, Manns Michael P, Färkkilä Martti, Vogel Arndt, Boberg Kirsten M, Schirmacher Peter, Karlsen Tom H

Abstract excerpt

BACKGROUND AND AIMS: Lifetime risk of biliary tract cancer (BTC) in primary sclerosing cholangitis (PSC) may exceed 20%, and BTC is currently the leading cause of death in patients with PSC. To open new avenues for management, we aimed to delineate clinically relevant genomic and pathological features of a large panel of PSC-associated BTC (PSC-BTC). APPROACH AND RESULTS: We analyzed formalin-fixed,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bile Duct Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cholangiocarcinoma

Share to Cholangitis, Sclerosing

Share to Cyclin-Dependent Kinase Inhibitor p16

Share to Genes, p53

Share to Genomics

Share to Proto-Oncogene Proteins p21(ras)

Share to Young Adult

Source

Open in PubMed

Identifiers

PMID: 31925805
DOI: 10.1002/hep.31110

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genomic Characterization of Cholangiocarcinoma in Primary Sclerosing Cholangitis Reveals Therapeutic Opportunities.PMID 31925805Read ↗

Comprehensive Genomic Profiles of Patients With Biliary Tract Cancer.Semantic proximity Read ↗

Translating cancer genomics for precision oncology in biliary tract cancers.Semantic proximity Read ↗

Molecular characterization of extrahepatic cholangiocarcinoma: perihilar and distal tumors display divergent genomic and transcriptomic profiles.Semantic proximity Read ↗

Genomic characterization of biliary tract cancers identifies driver genes and predisposing mutations.Semantic proximity Read ↗

Comparative analysis of genomic profiles and clinical outcomes in cholangiocarcinoma and gallbladder cancer.Semantic proximity Read ↗

Biliary tract cancers: epidemiology, molecular pathogenesis and genetic risk associations.Semantic proximity Read ↗

Actionable genomic landscape of biliary tract cancer in the Indian population.Semantic proximity Read ↗

Global patterns of mutational profiles in biliary tract cancer.Semantic proximity Read ↗

Genetic alterations during the neoplastic cascade towards cholangiocarcinoma in primary sclerosing cholangitis.Semantic proximity Read ↗

Genomic landscape of biliary tract cancer and corresponding targeted treatment strategiesSemantic proximity Read ↗

Mutational spectrum and precision oncology for biliary tract carcinoma.Semantic proximity Read ↗

Genomic profiling of idiopathic peri-hilar cholangiocarcinoma reveals new targets and mutational pathways.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.