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Article

Genomic profiling of idiopathic peri-hilar cholangiocarcinoma reveals new targets and mutational pathways.

Scientific reports - 24 Apr 2023

Quinn Leonard M, Haldenby Sam, Antzcak Philip, Fowler Anna, Bullock Katie, Kenny John, Gilbert Timothy, Andrews Timothy, Diaz-Nieto Rafael, Fenwick Stephen, Jones Robert, Costello-Goldring Eithne, Poston Graeme, Greenhalf William, Palmer Daniel, Malik Hassan, Goldring Chris

Abstract excerpt

Peri-hilar cholangiocarcinoma (pCCA) is chemorefractory and limited genomic analyses have been undertaken in Western idiopathic disease. We undertook comprehensive genomic analyses of a U.K. idiopathic pCCA cohort to characterize its mutational profile and identify new targets. Whole exome and targeted DNA sequencing was performed on forty-two resected pCCA tumors and normal bile ducts, with Gene Set Enrichment...

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Share to Bile Duct Neoplasms
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 37095160
DOI: 10.1038/s41598-023-33096-0
PMCID: PMC10126102

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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