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Article

Comparative analysis of genomic profiles and clinical outcomes in cholangiocarcinoma and gallbladder cancer.

Scientific reports - 8 Jun 2026

Lu Weiqun, Liu Rujiao, Liu Cuicui, Pang Jiaohui, Yin Jiani, Zhang Zhe

Abstract excerpt

Cholangiocarcinoma (CCA) and gallbladder cancer (GBC) exhibit distinct biological behaviors and treatment responses, potentially driven by differences in their genomic landscapes. However, genomic investigations of biliary tract carcinoma (BTC) remain limited. A retrospective analysis was performed on next-generation sequencing data from 258 patients with BTC (188 with CCA, 70 with GBC), with an external cohort...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 42259884
DOI: 10.1038/s41598-026-56230-0
PMCID: PMC13490447

Genes

BTC
MCL1
PBRM1
TERT
TP53
ARID1A
ARID2
CCNE1
CDKN2A
KRAS
SOX2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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