Article
Genomic characterization of biliary tract cancers identifies driver genes and predisposing mutations.
Journal of hepatology - 1 May 2018
Wardell Christopher P, Fujita Masashi, Yamada Toru, Simbolo Michele, Fassan Matteo, Karlic Rosa, Polak Paz, Kim Jaegil, Hatanaka Yutaka, Maejima Kazuhiro, Lawlor Rita T, Nakanishi Yoshitsugu, Mitsuhashi Tomoko, Fujimoto Akihiro, Furuta Mayuko, Ruzzenente Andrea, Conci Simone, Oosawa Ayako, Sasaki-Oku Aya, Nakano Kaoru, Tanaka Hiroko, Yamamoto Yujiro, Michiaki Kubo, Kawakami Yoshiiku, Aikata Hiroshi, Ueno Masaki, Hayami Shinya, Gotoh Kunihito, Ariizumi Shun-Ichi, Yamamoto Masakazu, Yamaue Hiroki, Chayama Kazuaki, Miyano Satoru, Getz Gad, Scarpa Aldo, Hirano Satoshi, Nakamura Toru, Nakagawa Hidewaki
Abstract excerpt
BACKGROUND & AIMS: Biliary tract cancers (BTCs) are clinically and pathologically heterogeneous and respond poorly to treatment. Genomic profiling can offer a clearer understanding of their carcinogenesis, classification and treatment strategy. We performed large-scale genome sequencing analyses on BTCs to investigate their somatic and germline driver events and characterize their genomic landscape. METHODS: We...
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