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Article

Global patterns of mutational profiles in biliary tract cancer.

Journal of hepatology - 1 Aug 2026

Zhu Yan, Wu Jason A, Zhang Dengyong, Chowdhury Saikat, Wang Huamin, Lee Sunyoung S, Meric-Bernstam Funda, Hu Zishuo I, Javle Milind, Kwong Lawrence N

Abstract excerpt

BACKGROUND & AIMS: Biliary tract cancers (BTCs) are a group of rare but highly lethal malignancies that include intrahepatic cholangiocarcinoma (iCCA), extrahepatic cholangiocarcinoma (eCCA), and gallbladder carcinoma (GBC). A major challenge in modeling and treating these cancers is their highly heterogeneous mutational landscapes, both within and across subtypes, as well as across geographic and etiological...

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Topics

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 41912087
DOI: 10.1016/j.jhep.2026.03.029

Genes

BTC
BAP1
CDKN2A
FGFR2
IDH1
IMPACT
KRAS
TP53

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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