Molecular characterization of extrahepatic cholangiocarcinoma: perihilar and distal tumors display divergent genomic and transcriptomic profiles.

doi:10.1080/14728222.2021.2013801

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Article

Molecular characterization of extrahepatic cholangiocarcinoma: perihilar and distal tumors display divergent genomic and transcriptomic profiles.

Expert opinion on therapeutic targets - 1 Dec 2021

Simbolo Michele, Bersani Samantha, Vicentini Caterina, Taormina Sergio V, Ciaparrone Chiara, Bagante Fabio, Rusev Borislav, Centonze Giovanni, Montresor Marina, Brunelli Matteo, Pedron Serena, Mafficini Andrea, Paolino Gaetano, Mattiolo Paola, Conci Simone, Milione Massimo, Guglielmi Alfredo, Ruzzenente Andrea, Scarpa Aldo, Luchini Claudio

Abstract excerpt

BACKGROUND: Extrahepatic cholangiocarcinoma (ECC) is classified into two subtypes based on anatomic origin: distal extrahepatic (DECC) and perihilar (PHCC) cholangiocarcinoma. This study aimed to shed light on its genomic and transcriptomic profiles. RESEARCH DESIGN AND METHODS: The genomic alterations of 99 ECC (47 PHCC and 52 DECC) were investigated by next-generation sequencing of 96 genes. A subgroup of...

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PMID: 34873971
DOI: 10.1080/14728222.2021.2013801

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