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Article

Genetic alterations during the neoplastic cascade towards cholangiocarcinoma in primary sclerosing cholangitis.

The Journal of pathology - 1 Nov 2022

Kamp Eline Jca, Dinjens Winand Nm, Doukas Michail, van Marion Ronald, Verheij Joanne, Ponsioen Cyriel Y, Bruno Marco J, Groot Koerkamp Bas, Trivedi Palak J, Peppelenbosch Maikel P, de Vries Annemarie C

Abstract excerpt

Carcinogenesis of primary sclerosing cholangitis (PSC)-associated cholangiocarcinoma (CCA) is largely unexplored. Improved understanding of the molecular events involved may guide development of novel avenues for rational clinical management. We aimed to assess the genetic alterations during progression of the neoplastic cascade from biliary dysplasia towards CCA in PSC. Forty-four resection specimens or biopsies...

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Share to Bile Duct Neoplasms
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Cholangitis, Sclerosing

Share to Class I Phosphatidylinositol 3-Kinases

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Source

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Identifiers

PMID: 35897137
DOI: 10.1002/path.5994
PMCID: PMC9825993

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