Article

Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene

2003-11-25

Abstract excerpt

Malignant cells often display defects in autophagy, an evolutionarily conserved pathway for degrading long-lived proteins and cytoplasmic organelles. However, as yet, there is no genetic evidence for a role of autophagy genes in tumor suppression. The beclin 1 autophagy gene is monoallelically deleted in 40–75% of cases of human sporadic breast, ovarian, and prostate cancer. Therefore, we used a targeted mutant mo...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: d891c2bc-10a6-5088-876d-66e038b932b3
DOI: 10.1172/jci200320039

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy geneDOI 10.1172/jci200320039Read

Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene.Semantic proximity Read

Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor.Semantic proximity Read

Role of autophagy in breast cancer.Semantic proximity Read

Autophagy gene haploinsufficiency drives chromosome instability, increases migration, and promotes early ovarian tumorsSemantic proximity Read

Beclin 1 restrains tumorigenesis through Mcl-1 destabilization in an autophagy-independent reciprocal mannerSemantic proximity Read

Induction of autophagy and inhibition of tumorigenesis by beclin 1Semantic proximity Read

Chronic Activation of mTOR Complex 1 Is Sufficient to Cause Hepatocellular Carcinoma in MiceSemantic proximity Read

The Biological Role and Clinical Significance of BECLIN-1 in CancerSemantic proximity Read

Autophagy regulator BECN1 suppresses mammary tumorigenesis driven by WNT1 activation and following parity.Semantic proximity Read

Why sick cells produce tumors: the protective role of autophagy.Semantic proximity Read

BRCA1 deficiency induces protective autophagy to mitigate stress and provides a mechanism for BRCA1 haploinsufficiency in tumorigenesisSemantic proximity Read

Autophagy mitigates metabolic stress and genome damage in mammary tumorigenesis.Semantic proximity Read