Article
Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene.
The Journal of clinical investigation - 1 Dec 2003
Qu Xueping, Yu Jie, Bhagat Govind, Furuya Norihiko, Hibshoosh Hanina, Troxel Andrea, Rosen Jeffrey, Eskelinen Eeva-Liisa, Mizushima Noboru, Ohsumi Yoshinori, Cattoretti Giorgio, Levine Beth
Abstract excerpt
Malignant cells often display defects in autophagy, an evolutionarily conserved pathway for degrading long-lived proteins and cytoplasmic organelles. However, as yet, there is no genetic evidence for a role of autophagy genes in tumor suppression. The beclin 1 autophagy gene is monoallelically deleted in 40-75% of cases of human sporadic breast, ovarian, and prostate cancer. Therefore, we used a targeted mutant...
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