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Article

Inflammation-induced endothelial-to-mesenchymal transition: a novel mechanism of intestinal fibrosis.

The American journal of pathology - 1 Nov 2011

Rieder Florian, Kessler Sean P, West Gail A, Bhilocha Shardul, de la Motte Carol, Sadler Tammy M, Gopalan Banu, Stylianou Eleni, Fiocchi Claudio

Abstract excerpt

In addition to mesenchymal cells, endothelial cells may contribute to fibrosis through the process of endothelial-to-mesenchymal transition (EndoMT). We investigated whether human intestinal microvascular endothelial cells (HIMEC) undergo EndoMT and contribute to fibrosis in human and experimental inflammatory bowel disease (IBD). HIMEC were exposed to TGF-β1, IL-1β, and TNF-α or supernatants of lamina propria...

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Source

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Identifiers

PMID: 21945322
DOI: 10.1016/j.ajpath.2011.07.042
PMCID: PMC3204019

Genes

TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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