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Article

TGF-beta1 gene transfer to the mouse colon leads to intestinal fibrosis.

American journal of physiology. Gastrointestinal and liver physiology - 1 Jul 2005

Vallance Bruce A, Gunawan M Imelda, Hewlett Bryan, Bercik Premysl, Van Kampen Corinne, Galeazzi Francesca, Sime Patricia J, Gauldie Jack, Collins Stephen M

Abstract excerpt

Crohn's disease (CD) is a chronic, relapsing inflammatory bowel disease, characterized by transmural inflammation. In CD, the recurrent inflammatory injury and tissue repair that occurs in the intestine can progress uncontrollably, leading to the proliferation of mesenchymal cells as well as fibrosis, characterized by excessive extracellular matrix deposition. These processes thicken the bowel wall, reducing...

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Identifiers

PMID: 15778431
DOI: 10.1152/ajpgi.00051.2005

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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