HDAC inhibition improves cardiopulmonary function in a feline model of diastolic dysfunction.

doi:10.1126/scitranslmed.aay7205

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Article

HDAC inhibition improves cardiopulmonary function in a feline model of diastolic dysfunction.

Science translational medicine - 8 Jan 2020

Wallner Markus, Eaton Deborah M, Berretta Remus M, Liesinger Laura, Schittmayer Matthias, Gindlhuber Juergen, Wu Jichuan, Jeong Mark Y, Lin Ying H, Borghetti Giulia, Baker Sandy T, Zhao Huaqing, Pfleger Jessica, Blass Sandra, Rainer Peter P, von Lewinski Dirk, Bugger Heiko, Mohsin Sadia, Graier Wolfgang F, Zirlik Andreas, McKinsey Timothy A, Birner-Gruenberger Ruth, Wolfson Marla R, Houser Steven R

Abstract excerpt

Heart failure with preserved ejection fraction (HFpEF) is a major health problem without effective therapies. This study assessed the effects of histone deacetylase (HDAC) inhibition on cardiopulmonary structure, function, and metabolism in a large mammalian model of pressure overload recapitulating features of diastolic dysfunction common to human HFpEF. Male domestic short-hair felines (n = 31, aged 2 months)...

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Identifiers

PMID: 31915304
DOI: 10.1126/scitranslmed.aay7205
PMCID: PMC7065257

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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